Although there are multiple paths and algorithms to a final diagnosis, the diagnostic strategy for LSDs still mostly relies on initial clinical suspicion followed by adequate spe- cialist and laboratory management – a selective screening approach. The efficacy of many cur- rent and proposed therapies relies heavily upon early detec- tion and treatment prior to the onset of irreversible patholo- gy. J Med Biochem 2014 33 (1) DOI: 10.2478/jomb-2013-0044 UDK 577.1 : 61 ISSN 1452-8258 J Med Biochem 33: 82–87, 2014 Review article Pregledni ~lanak INTEGRATIVE ALGORITHMS IN THE DIAGNOSTICS OF LYSOSOMAL STORAGE DISEASES INTEGRATIVNI ALGORITMI U DIJAGNOSTICI POREME]AJA U SKLADI[TENJU LIZOZOMA Ksenija Fumi} 1,2, Karmen Bili} 1, Dunja Rogi} 1,2 1 Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia 2 Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia Address for correspondence: Ksenija Fumi} fax:+385 2367 395 Tel:+385 91 4629921 e-mail: kfumicªkbc-zagreb.hr Summary Lysosomal storage disorders (LSDs) are a clinically heteroge- neous group of more than 50 disorders which still represent a challenge in modern medicine.
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